Selected publications

Xin-Xiang Lim, Bo Shu, Shuijun Zhang, Aaron W K Tan, Thiam-Seng Ng, Xin-Ni Lim, Valerie S-Y Chew, Jian Shi, Gavin R Screaton, Shee-Mei Lok*, Ganesh S Anand*. (2021). Human antibody C10 neutralizes by diminishing Zika but enhancing dengue virus dynamics. Cell, 184(25):6067-6080.e13. 
*co-lead contacts/corresponding authors
PMID: 34852238
Guntur Fibriansah, Elisa X. Y. Lim, Jan K. Marzinek, Thiam-Seng Ng, Joanne L. Tan, Roland G. Huber, Xin-Ni Lim, Valerie S. Y. Chew, Victor A. Kostyuchenko, Jian Shi, Ganesh S. Anand, Peter J. Bond, James E. Crowe Jr., Shee-Mei Lok. (2021). Antibody affinity versus dengue morphology influences neutralization. PLoS Pathog., 17(2):e1009331.
PMID: 33621239
Qun Fei Zhou, Julie M Fox, James T Earnest, Thiam-Seng Ng, Arthur S Kim, Guntur Fibriansah, Victor A Kostyuchenko, Jian Shi, Bo Shu, Michael S Diamond, Shee-Mei Lok. (2020). Structural basis of Chikungunya virus inhibition by monoclonal antibodies. Proc Natl Acad Sci U S A, 117(44):27637-27645.
PMID: 33087569
Seamus R Morrone, Valerie S Y Chew, Xin-Ni Lim, Thiam-Seng Ng, Victor A Kostyuchenko, Shuijun Zhang, Melissa Wirawan, Pau-Ling Chew, Jaime Lee, Joanne L Tan, Jiaqi Wang, Ter Yong Tan, Jian Shi, Gavin Screaton, Marc C Morais, Shee-Mei Lok. (2020). High flavivirus structural plasticity demonstrated by a non-spherical morphological variant. Nature communications, 11(1), 3112.
PMID: 32561757
Shuijun Zhang, Thomas Loy, Thiam-Seng Ng, Xin-Ni Lim, Shyn-Yun Valerie Chew, Ter Yong Tan, Meihui Xu, Victor A. Kostyuchenko, Farhana Tukijan, Jian Shi, Katja Fink, Shee-Mei Lok. (2020). A Human Antibody Neutralizes Different Flaviviruses by Using Different Mechanisms. Cell reports, 31(4), 107584.
PMID: 32348755
Ter Yong Tan, Guntur Fibriansah, Victor A. Kostyuchenko, Thiam-Seng Ng, Xin-Xiang Lim, Shuijun Zhang, Xin-Ni Lim, Jiaqi Wang, Jian Shi, Marc C. Morais, Davide Corti, and Shee-Mei Lok. (2020). Capsid protein structure in Zika virus reveals the flavivirus assembly process. Nat Commun. 11(1):895.
PubMed ID: 32060358
Xin-Ni Lim, Chao Shan, Jan K. Marzinek, Hongping Dong, Thiam Seng Ng, Justin S. G. Ooi, Guntur Fibriansah, Jiaqi Wang, Chandra S. Verma, Peter J. Bond, Pei-Yong Shi, Shee-Mei Lok. (2019). Molecular basis of dengue virus serotype 2 morphological switch from 29°C to 37°C. (2019). PLoS Pathog. 15(9):e1007996.
PubMed ID: 31536610
Melissa Wirawan, Guntur Fibriansah, Jan K. Marzinek, Xin Xiang Lim, Thiam-Seng Ng, Adelene Y. L. Sim, Qian Zhang, Victor A. Kostyuchenko, Jian Shi, Scott A. Smith, Chandra S Verma, Ganesh Anand, James E. Crowe Jr., Peter J. Bond & Shee-Mei Lok. (2018). Mechanism of enhanced immature dengue virus attachment to endosomal membrane induced by prM antibody. Structure, 27(2):253-267.e8.
Pubmed ID: 30471923
Jiaqi Wang, Marco Bardelli, Diego A. Espinosa, Mattia Pedotti, Thiam-Seng Ng, Siro Bianchi, Luca Simonelli, Elisa X.Y. Lim, Mathilde Foglierini, Fabrizia Zatta, Stefano Jaconi, Martina Beltramello, Elisabetta Cameroni, Guntur Fibriansah, Jian Shi, Taylor Barca, Isabel Pagani, Alicia Rubio, Vania Broccoli, Elisa Vicenzi, Victoria Graham, Steven Pullan, Stuart Dowall, Roger Hewson, Simon Jurt, Oliver Zerbe, Karin Stettler, Antonio Lanzavecchia, Federica Sallusto, Andrea Cavalli, Eva Harris, Shee-Mei Lok*, Luca Varani*, Davide Corti*. (2017). A human bi-specific antibody against Zika virus with high therapeutic potential. Cell, 171(1):229-241.
Pubmed ID: 28938115
*co-corresponding authors.
Shuijun Zhang, Victor A. Kostyuchenko, Thiam-Seng Ng, Xin-Ni Lim, Justin S.G. Ooi, Sebastian Lambert, Ter Yong Tan, Douglas G. Widman, Jian Shi, Ralph S. Baric and Shee-Mei Lok. (2016). Neutralization mechanism of a highly potent antibody against Zika virus. Nature Communications, 7:13679.
Pubmed ID: 27882950
Victor A. Kostyuchenko, Elisa X. Y. Lim, Shuijun Zhang, Guntur Fibriansah, Thiam-Seng Ng, Justin S. G. Ooi, Jian Shi. and Shee-Mei Lok. (2016). Structure of the thermally stable Zika virus. Nature. 533(7603):425-428.
Pubmed ID: 27093288
Guntur Fibriansah, Kristie D. Ibarra, Thiam-Seng Ng, Scott A. Smith, Joanne L. Tan, Xin-Ni Lim, Justin S. G. Ooi, Victor A. Kostyuchenko, Jiaqi Wang, Aravinda M. de Silva, Eva Harris, James E. Crowe, Jr. and Shee-Mei Lok. (2015). DENGUE VIRUS: Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers. Science. 349(6243):88-91.
Pubmed ID: 26138979
#highlighted article in Science, commentary articles on this paper is published in the journals “Nature Reviews Drug Discovery” and “Nature”.
Guntur Fibriansah, Joanne L. Tan, Scott A. Smith, Ruklanthi de Alwis, Thiam-Seng Ng, Victor A. Kostyuchenko, Ramesh S. Jadi, Petra Kukkaro, Aravinda M. de Silva, James E. Crowe, Jr. and Shee-Mei Lok. (2015). A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins. Nature Communications, 6:6341.
Pubmed: 25698059
Victor A. Kostyuchenko, Pau Ling Chew, Thiam-Seng Ng, and Shee-Mei Lok. (2014). Near-atomic resolution cryo-EM structure of Dengue serotype 4 virus. Journal of Virology, 88(1):477-482.
Pubmed ID: 24155405
#Selected for cover page and highlighted in a review in Current Opinion in Virology
Guntur Fibriansah, Joanne L. Tan, Ruklanthi de Alwis, Scott A. Smith, Thiam-Seng Ng, Victor A. Kostyuchenko, Kristie D. Ibarra, Eva Harris, Aravinda de Silva, James E. Crowe, Jr. and Shee-Mei Lok. (2014). A potent anti-dengue human antibody preferentially recognizes the conformation of E protein monomers assembled on the virus surface. EMBO Molecular Medicine. 6(3):358-71.
Pubmed : 24421336
#Selected for cover page
Guntur Fibriansah, Thiam-Seng Ng, Victor A. Kostyuchenko, Jaime Lee, Sumarlin Lee, Jiaqi Wang, and Shee-Mei Lok. (2013). Structural changes in Dengue virus when exposed to a temperature of 37 deg. C. Journal of Virology, 87(13):7585-92.
Pubmed ID: 23637405
#Selected for cover page and the article was featured in a Nature commentary article and also a review in Current Opinion in Virology
Victor A. Kostyuchenko, Qian Zhang, Joanne L. Tan, Thiam-Seng Ng, and Shee-Mei Lok. (2013). Immature and mature Dengue serotype 1 virus structures provide insight into the maturation process. Journal of Virology. 87(13):7700-7707.
Pubmed ID: 23637416
#this paper featured in a review in Trends in Microbiology
Qian Zhang, Cornelia Hunke, Yin-Hoe Yau, Vernon Seow, Sumarlin Lee, Lukas Bahati Tanner, Xue Li Guan, Markus R Wenk, Guntur Fibriansah, Pau Ling Chew, Petra Kukkaro, Goran Biuković, Pei-Yong Shi, Susana Geifman Shochat, Gerhard Grüber and Shee-Mei Lok. (2012). The stem region of premembrane protein plays an important role in the virus surface protein rearrangement during dengue maturation. Journal of Biological Chemistry. 287(48):40525-40534.
Pubmed ID: 23035113
Ee Ping Teoh, Petra Kukkaro, En Wei Teo, Angeline Lim, Tze Tong Tan, Andy Yip, Wouter Schul, Myint Aung, Victor A. Kostyuchenko, Yee Sin Leo, Soh Ha Chan, Kenneth G.C. Smith, Eng Eong Ooi, D. Michael Kemeny, Grace K. Tan,  Jowin K. W. Ng, Mah Lee Ng, Sylvie Alonso, Pei Yong Shi, Dale Fisher, Brendon Hanson, Shee-Mei Lok* and Paul A. MacAry*. (2012). The Structural Basis for Serotype-Specific Neutralization of Dengue Virus by a Natural Human Antibody. Science Translational Medicine. 4(139):139ra83.
*co-corresponding authors
Pubmed ID: 22723463
Long Li, Shee-Mei Lok, I-Mei Yu, Ying Zhang, Richard J. Kuhn, Jue Chen, Michael G. Rossmann. (2008). The flavivirus precursor membrane-envelope protein complex: structure and maturation. Science. 319: 1830-1834.
Pubmed ID: 18369147
Shee-Mei Lok, Victor Kostyuchenko, Grant E. Nybakken, Heather A. Holdaway, Anthony J. Battisti, Soila Sukupolvi-Petty, Dagmar Sedlak, Daved H. Fremont, Paul R. Chipman, John T. Roehrig, Michael S. Diamond, Richard J. Kuhn & Michael G. Rossmann. (2008). Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins. Nature Structural and Molecular Biology. 15 (3): 312-317.
Pubmed ID: 18264114