Shee-Mei Lok, PhD
Dr Shee-Mei Lok is a Provost's Chair Professor and a Professor in the Emerging Infectious Disease programme, Duke-NUS Medical School and the Department of Biological Sciences, NUS. She was a National Research Foundation Fellow in year 2009 to 2014 and is now a NRF Investigator. She is a structural virologist specializing in X-ray crystallography and cryo-electron microscopy. Her research focuses on the structural changes of flavivirus and alphavirus during its infection cycle and the effect of anti-viral therapeutics on the virus particle.
She obtained her PhD from NUS in 2004 specializing on x-ray crystallography. She did her post-doctoral training in Purdue University under the supervision of the late Prof Michael Rossmann from 2004 till 2009. She served as visiting Assistant Professor in Baylor College of Medicine in the year 2010 in the laboratory of Prof Wah Chiu.
She obtained her PhD from NUS in 2004 specializing on x-ray crystallography. She did her post-doctoral training in Purdue University under the supervision of the late Prof Michael Rossmann from 2004 till 2009. She served as visiting Assistant Professor in Baylor College of Medicine in the year 2010 in the laboratory of Prof Wah Chiu.
Education/Training
Ngee Ann Polytechnic, Singapore. 1993. Diploma in Biotechnology.
Queensland University of Technology, Australia. 1994. Bsc. Biochemistry/ Microbiology.
Queensland University of Technology, Australia. 1995. Bsc(Hons). Virology/ Immunology.
National University of Singapore, Singapore. 1999. Msc. Virology/ Immunology.
National University of Singapore/ Institute of Molecular and Cell Biology, Singapore. 2005. PhD. X-ray Crystallography.
Queensland University of Technology, Australia. 1994. Bsc. Biochemistry/ Microbiology.
Queensland University of Technology, Australia. 1995. Bsc(Hons). Virology/ Immunology.
National University of Singapore, Singapore. 1999. Msc. Virology/ Immunology.
National University of Singapore/ Institute of Molecular and Cell Biology, Singapore. 2005. PhD. X-ray Crystallography.
Positions
1996-1998 Postgraduate Research Scholar in the National University of Singapore.
1999-2004 Junior research fellow in the Institute of Molecular and Cell Biology, Singapore.
2004-2008 Post-doctoral researcher in the laboratory of Michael Rossmann, Purdue University, USA.
2009-2010 Visiting Assistant Professor, Baylor College of Medicine, Houston, Texas.
2009–2014 National Research Foundation fellow, NRF, Singapore
2009–2014 Assistant Professor, Duke-NUS
2009–current Principal Investigator, Center for Bioimaging Sciences, NUS, Singapore
2014–2018 Associate Professor, in both Duke-NUS, and DBS, NUS
2016-2022 National Research Foundation Investigator, NRF, Singapore
2019–current Professor, in both Duke-NUS and DBS, NUS
2021-current Member of the NTU Institute of Structural Biology
2021-current Provost’s Chair professor in Duke-NUS and DBSNUS
2024-2025 Deputy director in the Emerging Infectious Diseases programme, Duke-NUS
2024 Vice-Chair of Duke-NUS APT promotion committee.
2025 Member of the NUS UPTC (University promotion and tenure committee)
2026-current Interim Vice dean of Research, Duke-NUS Medical School
1999-2004 Junior research fellow in the Institute of Molecular and Cell Biology, Singapore.
2004-2008 Post-doctoral researcher in the laboratory of Michael Rossmann, Purdue University, USA.
2009-2010 Visiting Assistant Professor, Baylor College of Medicine, Houston, Texas.
2009–2014 National Research Foundation fellow, NRF, Singapore
2009–2014 Assistant Professor, Duke-NUS
2009–current Principal Investigator, Center for Bioimaging Sciences, NUS, Singapore
2014–2018 Associate Professor, in both Duke-NUS, and DBS, NUS
2016-2022 National Research Foundation Investigator, NRF, Singapore
2019–current Professor, in both Duke-NUS and DBS, NUS
2021-current Member of the NTU Institute of Structural Biology
2021-current Provost’s Chair professor in Duke-NUS and DBSNUS
2024-2025 Deputy director in the Emerging Infectious Diseases programme, Duke-NUS
2024 Vice-Chair of Duke-NUS APT promotion committee.
2025 Member of the NUS UPTC (University promotion and tenure committee)
2026-current Interim Vice dean of Research, Duke-NUS Medical School
Awards
1. Recipient of the prestigious National Research Foundation Fellowship award, Singapore. 2009
2. Recipient of the prestigious National Research Foundation Investigatorship award, Singapore 2016
3. One of the 25 alumni members who received the Ngee Ann Polytechnic Alumni Award for making a difference in Science and Technology 2013
4. Named as one of the “The 7 scientists from Singapore to watch” by Asian Scientist, 2016
(http://www.asianscientist.com/2016/06/features/7-scientists-singapore-watch/)
2. Recipient of the prestigious National Research Foundation Investigatorship award, Singapore 2016
3. One of the 25 alumni members who received the Ngee Ann Polytechnic Alumni Award for making a difference in Science and Technology 2013
4. Named as one of the “The 7 scientists from Singapore to watch” by Asian Scientist, 2016
(http://www.asianscientist.com/2016/06/features/7-scientists-singapore-watch/)
Participate in peer review for journals:
Science, Nature, Nature structural and molecular biology, Nature Communications, Science Advances, PNAS, PLOS pathogen, MBio, Trends in Microbiology, Journal of Virology, Virology, Antiviral research, PLOS Neglected Tropical Diseases, Journal of General Virology
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